Medication Side Effect: Depersonalization

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Reader’s Question

I have what I consider to be depersonalization as a side effect of my medication. Sometimes it is very mild, but sometimes it is so annoying. Will this ever go away? What are the signs that it may be diminishing?

Psychologist’s Reply

Medication side effects can be frustrating, uncomfortable, and at times scary. Depersonalization is the experience of feeling detached from your body or your thoughts, as if things are unreal. Some people experience a sensation of being outside of the body or disconnected from what is happening around them. Although it is a strange sensation (and annoying, as you said!), it is not dangerous. It sounds like it comes and goes for you. When depersonalization occurs, remind yourself that it will pass and that you are safe.

Depersonalization can be caused by different things, including acute anxiety or panic, a history of trauma, sleep deprivation, and even emotionally stressful situations. Temporary depersonalization can also occur as a side effect of some medications, as in your case.

Some side effects are most noticeable when you first start to take the medication, and go away as your body adjusts. Other side effects continue as long as you take the medication.

If it is an initial side effect, you should notice the frequency and length of episodes of depersonalization decreasing. If moments of depersonalization continue to bother you after a couple months, consult with your medical practitioner to discuss your options. It may be that you need to adjust the dose or the medication itself to achieve the best results.

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